A 48-year-old woman with a history of hypertension, hypothyroidism, diabetes, and dyslipidemia comes to your primary care office to establish care. She recently moved from another state. Her current medications include hydrochlorothiazide, levothyroxine, metformin, and colesevelam, which was prescribed after she experienced severe myalgias with atorvastatin. Which of the following adverse effects is this patient most likely to experience with colesevelam?