A 32-year-old female patient presents to the emergency department with sudden-onset abdominal pain and a history of easy bruising since childhood. She reports a family history of unexplained arterial ruptures and has previously been diagnosed with Vascular Ehlers-Danlos Syndrome (vEDS). Genetic testing confirmed a mutation in the COL3A1 gene. Physical examination reveals a thin, translucent skin appearance and hypermobile joints. Given her diagnosis and the molecular basis of vEDS, the medical team considers the underlying pathology to guide management. Based on the molecular pathology of Vascular Ehlers-Danlos Syndrome (vEDS) involving dominant negative mutations in the COL3A1 gene, which of the following best describes the primary consequence in affected tissues?
