IgG,IgM, IgA mediated Sensitization: ‘freely circulating’ soluble antigens elicit T and B cell activation Immunologic reaction: IgG or IgM antibodies bind with circulating antigens, form an immune complex and deposit in tissue. They activate complement cascade, attract neutrophils leading to the release of lysosomal enzymes and an inflammatory response in tissues. Typical Time of Onset: […]
A 3 year-old male is brought to your office for the evaluation of recurrent infections and persistent hunger, and not gaining weight. His mother reports that his medical history is significant for recurrent skin abscesses with staphylococcus aureus. Recently he started to complain about abdominal pain that starts one to two hours after a meal. […]
A 7 year-old male comes to your clinic with a large blister on his left foot. They come and disappear after a few days. Occasionally, he also develops swollen lips, swollen tongue, colicky abdominal pain with these blisters. Blisters are not itchy but slightly painful. These episodes come every few months and last for 1-2 […]
Key Points Granulomatosis with polyangiitis is a systemic necrotizing, mostly small vessel vasculitis of unknown etiology that manifests as granulomatous lesions of the upper respiratory tract, lungs and kidneys. -Formerly known as Wegener Granulomatosis, it was renamed because of the eponymous individual’s association with Nazism -GPA is the most common form of vasculitis to involve […]
Key Points Adenosine Deaminase Deficiency, a form of Severe Combined Immunodeficiency (SCID), is a purine metabolic disorder caused by mutations in the ADA gene, resulting in immunodeficiency and its complications. -It was first discovered in 1972 by American genetic scientist, Eloise Giblett. -In 1990, it was the first pathophysiologic condition to be treated by gene […]
