For which of the following medical conditions are fibrates commonly used as a treatment?

A 39 year-old woman comes to your primary care center complaining of right upper quadrant abdominal pain, indigestion and nausea. She has been taking warfarin for a recent deep venous thrombosis in right lower extremity. Family history reveals that several members of her family, including her mother and a sister, suffer from an inherited metabolic disorder. On physical examination you notice yellowing of the skin and eyes; moderate hepatosplenomegaly; tenderness in the right upper quadrant, epigastric area and middle quadrant. You also notice small, nonpainful orange-red papules on his scalp, elbows and knees and a yellow-to-orange coloration of palmar and finger creases. Laboratory tests reveal elevated amylase, lipase; elevated triglyceride level of 1700 mg/dL; elevated VLDL, and elevated total cholesterol. Abdominal ultrasound revealed stones in the gallbladder. Patient was admitted to the local hospital and had a cholecystectomy. At the time of her discharge, you begin her on a triglyceride-lowering agent. Which of the following is the first-line treatment to treat this patient’s hypertriglyceridemia?

Which of the following patients is ideal for treatment with alirocumab?

A 48-year-old woman with a history of hypertension, hypothyroidism, diabetes, and dyslipidemia comes to your primary care office to establish care. She recently moved from another state. Her current medications include hydrochlorothiazide, levothyroxine, metformin, and colesevelam, which was prescribed after she experienced severe myalgias with atorvastatin. Which of the following adverse effects is this patient most likely to experience with colesevelam?

A 34 year-old female who is 12 weeks pregnant comes to your office for initiation of treatment for her hypertension. Of the following, which medication is useful to treat her hypertension?

Of the following, which is the best description of the mechanism of action of hydralazine?

A 48-year-old woman comes to your primary care clinic complaining of a facial rash,joint pains and photosensitivity. In the review of systems, she reports fever, hair loss, headaches, flushing, palpitations, feeling low, tingling sensation in both feet and peripheral edema. While reviewing her medications, she informs you that she started on a new medication 4 months ago. On physical examination, you observe that the patient has flushing of her cheeks with a distinct butterfly rash over her nose and cheeks. Her temperature is 99 °F (37.2 °C), heart rate is 108 beats/min, blood pressure is 148/98 mm Hg, respirations are 19 breaths/min, and oxygen saturation is 98% on room air. Laboratory studies are significant for the presence of anti-histone antibodies. Which of the following medications is most likely causing her distress?

A 72 year-old male presents to the emergency room with severe chest pain, nausea and vomiting. His past medical history is significant for hypertension and he has been taking lisinopril 20 mg daily for hypertension. His ECG displayed ST segment elevations in precordial leads. Lab tests revealed elevated troponin. His temperature is 99 ⁰ F, heart rate is 97 beats per minute, respiratory rate is 17 breaths per minute, and blood pressure is 220/140 mm Hg. Which of the following is the most effective way to reduce his blood pressure?

A 24-year-old female presents with severe, recalcitrant acne that has persisted for five years. She reports painful cystic lesions predominantly on her face, chest, and back, which have left deep, atrophic scars. Her acne significantly affects her self-esteem and has led to social withdrawal and mild depressive symptoms. She has tried multiple treatments, including topical retinoids, benzoyl peroxide, salicylic acid, and oral antibiotics (minocycline), with minimal success. She also attempted hormonal therapy with combined oral contraceptives but discontinued after experiencing side effects, including nausea and headaches. Frustrated with the lack of improvement, she seeks more definitive treatment. She is sexually active and uses condoms inconsistently for contraception. She is being initiated on isotretinoin at 0.5 mg/kg/day. What is the most critical precaution when prescribing isotretinoin to a female patient of childbearing age?

A 68 year-old woman comes to your primary clinic complaining of ringing in the ears, hearing loss, lightheadedness, and a feeling that something is ‘stuffed in my ears’. She reports that these symptoms started after she was initiated on a ‘kidney pill’. Of the following, which is the most likely culprit?