A 22-year-old woman presents to the clinic for evaluation of chronic joint pain. She reports frequent joint dislocations with minimal trauma, delayed wound healing, and easy bruising. On examination, she has hyperextensible skin, atrophic scars on her knees and elbows, and generalized joint hypermobility. Cardiac auscultation reveals a mid-systolic click. Which of the following best explains the pathogenesis of this patient’s condition?
