A 25-year-old male patient with a rare neurodegenerative disorder presents with tremors, cognitive decline, and protein aggregates in his brain tissue on autopsy. Genetic testing reveals a mutation affecting an E3 ligase involved in the ubiquitin-proteasome pathway, leading to the accumulation of misfolded proteins. Question: Which of the following best explains how a dysfunctional E3 ligase contributes to protein aggregation in this patient?
