A 45-year-old man with a history of renal transplantation presents with blurred vision and floaters in his right eye. He reports no pain but has noticed progressive visual deterioration over the past week. Ophthalmologic examination reveals yellow-white retinal lesions with surrounding inflammation and vitritis. He is on immunosuppressive therapy, including prednisone and tacrolimus. Question: Which of the following is the most appropriate initial treatment for this patient?