A 55-year-old man with a history of gout presents to the clinic with recurrent joint pain and swelling in his big toe. His condition is linked to an imbalance between purine and pyrimidine nucleotide synthesis. His physician explains that nucleotide biosynthesis is regulated by allosteric effectors, including ATP and CTP, which influence the enzyme aspartate transcarbamoylase (ATCase). Which of the following best describes the regulation of ATCase?
