Patient Case: A 38-year-old man with known HIV infection presents with a 2-month history of chronic watery diarrhea, unintentional weight loss, and significant fatigue. His CD4 count is 50 cells/µL. He also reports difficulty swallowing over the past week. Stool testing confirms Cryptosporidium oocysts, and an endoscopy reveals white plaques in the esophagus consistent with Candida infection. Which of the following is considered an AIDS (HIV Stage 3)-defining illness?