A 22 year-old student from Italy visits your office for poor appetite, tiredness and weakness. You ran some laboratory tests which are significant for the following values. Hemoglobin: 10 g/dL (Normal 13.5-17.5 g/dL) Mean corpuscular volume (MCV): 55 μ m³ (80-100 μ m³) Red blood cell distribution width (RDW): 12.5% ( Normal range 11.5% to 14.5%) Serum ferritin: 170 (Normal 20-250 ng/mL) Hemoglobin electrophoresis: Hemoglobin A 87%; Hemoglobin A2 8%, Hemoglobin F 5% What is the most likely diagnosis in this patient?
A 67 year-old male patient came to your office for an annual physical examination and laboratory tests which are required by his health insurance company. He denies any symptoms such as fatigue, weakness, shortness of breath or chest pain.His CBC is significant for microcytic anemia. He reports that years ago he was diagnosed with a β-Thalassemia trait. What is the next best step in the management of this patient?
You are about to prescribe a few medications to someone who has been diagnosed with thalassemia. Which of the following medications is known to put oxidative stress on red blood cells even at therapeutic doses?
Of the following, what is the most common complication with which most patients with thalassemia major die of after receiving multiple transfusions?
A 19 year-old female arrives in your office to start her treatment on hydroxyurea for the management of sickle cell disease. Which of the following tests is indicated before you start her on hydroxyurea?
You are going to start a patient on the medication hydroxyurea for a long standing disorder. Which of the following statements is true regarding hydroxyurea?
