A 55 year-old man comes to your office with complaints of gradual breast enlargement over the past 3 months. He has mild tenderness in both breasts, more pronounced on the left side. He also describes psychological discomfort about his appearance, explaining the feelings of embarrassment. His medical history is significant for hypertension, chronic heart failure (NYHA Class II), and type 2 diabetes mellitus. His current medications include spironolactone, metoprolol, metformin, furosemide and aspirin. He does not consume alcohol excessively and denies use of anabolic steroids or recreational drugs. He has no family history of breast cancer or hormonal disorders. On physical examination, you notice a well-appearing male. His blood pressure is 128/80 mm Hg and heart rate is 72 bpm. He has enlarged breasts, but no discharge or lumps. There is mild tenderness on palpation of both breasts. There is no nipple retraction or discharge. Which of his current medications most likely caused his breast condition?

A 58-year-old man presents to your office with progressive dyspnea over the last three months. Previously, he had been able to work in his farm and take care of his cows, but now he feels short of breath after walking only 50 feet. He does not have chest pain at rest but has experienced retrosternal chest pressure with strenuous work. His sleep is also not ‘peaceful’ because he wakes up at night feeling short of breath, which is relieved within minutes by sitting upright in bed. On physical examination, he is afebrile, with a heart rate of 88 beats per minute (bpm), blood pressure of 145/92 mm Hg, and respiratory rate of 18 breaths per minute. On cardiac examination, his heart rhythm is regular with a normal S1 and S2 with a systolic murmur loudest over the second right intercostal space. He also has elevated jugular venous pressure (JVP), pedal edema and bilateral crackles in lungs. Echocardiogram reveals an ejection fraction of 30% and aortic stenosis. Which of the following medications is shown to improve long-term survival in this patient?