A 57 year-old male patient is brought to the emergency room by his daughter because he has been ‘vomiting non stop’ since this morning and not responding to her questions appropriately. He developed a slurred speech and she can’t understand what he has been saying. His daughter reports that the patient has been having problems with his vision lately and probably could have taken tablets which belong to his son, who is on treatment for tuberculosis and takes isoniazid and rifampin daily. His temperature is 100.7 ⁰ F, heart rate is 84 beats per minute, respiratory rate is 7 breaths per minute, and blood pressure is 90/64 mm Hg. As you listen to his lungs, he developed a tonic-clonic seizure. Which of the following is a true statement regarding isoniazid overdose?

A 32 year-old male comes to your ophthalmology clinic complaining of increasingly blurry vision and headaches. His wife reports that his gait became clumsy, his speech became slurred. On review of systems, you discover that he has difficulty swallowing, and having frequent headaches. Patient reports that some of his relatives also have similar medical problems. On physical examination, you notice a sweaty, anxious looking male. Cardiac exam is significant for palpitations. In retinal exam, you find dilation and tortuosity of retinal vessels, angiomatous lesions with hemorrhages and exudates in both eyes. Suspecting a systemic disorder, you order some investigative studies, which reveal hemangioblastomas in the cerebellum, two nodules in the pancreas and a large tumor in the kidney. The lesions have a striking appearance of a cyst with a nodule contained in its wall, and angiography demonstrates the highly vascular nature of the nodules. The laboratory tests reveal elevated plasma free fractionated metanephrines, and elevated red blood cells, white blood cells and platelets. Of the following, which is the chromosomal location of the gene affected in this disorder?

A 32 year-old male comes to your ophthalmology clinic complaining of increasingly blurry vision and headaches. His wife reports that his gait became clumsy, his speech became slurred. On review of systems, you discover that he has difficulty swallowing, and having frequent headaches. Patient reports that some of his relatives also have similar medical problems. On physical examination, you notice a sweaty, anxious looking male. Cardiac exam is significant for palpitations. In retinal exam, you find dilation and tortuosity of retinal vessels, angiomatous lesions with hemorrhages and exudates in both eyes. Suspecting a systemic disorder, you order some investigative studies, which reveal hemangioblastomas in the cerebellum, two nodules in the pancreas and a large tumor in the kidney. The lesions have a striking appearance of a cyst with a nodule contained in its wall, and angiography demonstrates the highly vascular nature of the nodules. The laboratory tests reveal elevated plasma free fractionated metanephrines, and elevated red blood cells, white blood cells and platelets. The erythrocytosis in this patient is most likely due to which of the following?

A 32 year-old male comes to your ophthalmology clinic complaining of increasingly blurry vision and headaches. His wife reports that his gait became clumsy, his speech became slurred. On review of systems, you discover that he has difficulty swallowing, and having frequent headaches. Patient reports that some of his relatives also have similar medical problems. On physical examination, you notice a sweaty, anxious looking male. Cardiac exam is significant for palpitations. In retinal exam, you find dilation and tortuosity of retinal vessels, angiomatous lesions with hemorrhages and exudates in both eyes. Suspecting a systemic disorder, you order some investigative studies, which reveal hemangioblastomas in the cerebellum, two nodules in the pancreas and a large tumor in the kidney. The lesions have a striking appearance of a cyst with a nodule contained in its wall, and angiography demonstrates the highly vascular nature of the nodules. The laboratory tests reveal elevated plasma free fractionated metanephrines, and elevated white blood cells, red blood cells and platelets. The diagnosis of this disease can be confirmed by the presence of a mutation on which of the following chromosomes?

A 32 year-old male comes to your ophthalmology clinic complaining of increasingly blurry vision and headaches. His wife reports that his gait became clumsy, his speech became slurred. On review of systems, you discover that he has difficulty swallowing, and having frequent headaches. Patient reports that some of his relatives also have similar medical problems.      On physical examination, you notice a sweaty, anxious looking male. Cardiac exam is significant for palpitations. In retinal exam, you find dilation and tortuosity of retinal vessels, angiomatous lesions with hemorrhages and exudates in both eyes. Suspecting a systemic disorder, you order some investigative studies, which reveal hemangioblastomas in the cerebellum, two nodules in the pancreas  and a large tumor in the kidney. The lesions have a striking appearance of a cyst with a nodule contained in its wall, and angiography demonstrates the highly vascular nature of the nodules. The laboratory tests reveal elevated plasma free fractionated metanephrines, and elevated white blood cells, red blood cells and platelets.  Of the following, which is the most likely diagnosis in this patient? 

A 46 yo male is brought to your office by his wife for the evaluation of his symptoms. She reports that for the last 8 months, the patient has lost all ‘norms of decency’. He is touching his private parts in public places. He is undressing and exposing his genitals to strangers. He has difficulty remembering things. A few months ago, on a flight from Los Angeles to New York, he allegedly touched a fellow passenger inappropriately and was arrested by the federal aviation authorities. He pleaded guilty to a misdemeanor and was sentenced to a federal prison for 3 months. Prison health records show that he has had a tendency to explore objects by placing them in the mouth together with the indiscriminate eating or chewing of objects and all kinds of food. He reports that he has no other way to recognize objects as he cannot see them properly. His past medical history is significant for herpes simplex encephalitis and a head injury a year ago. In the physical examination, you notice a very passive individual with a flat affect and reduced response to your greetings,but he follows your commands well. He exhibits excessive attentiveness to visual stimuli with a tendency to touch every object. This disorder is due to lesions affecting which of the following regions in the brain?

A 46 yo male is brought to your office by his wife for the evaluation of his symptoms. She reports that for the last 8 months, the patient has lost all ‘norms of decency’. He is touching his private parts in public places. He is undressing and exposing his genitals to strangers. He has difficulty remembering things. A few months ago, on a flight from Los Angeles to New York, he allegedly touched a fellow passenger inappropriately and was arrested by the federal aviation authorities. He pleaded guilty to a misdemeanor and was sentenced to a federal prison for 3 months. Prison health records show that he has had a tendency to explore objects by placing them in the mouth together with the indiscriminate eating or chewing of objects and all kinds of food. He reports that he has no other way to recognize objects as he cannot see them properly. His past medical history is significant for herpes simplex encephalitis and a head injury a year ago. In the physical examination, you notice a very passive individual with a flat affect and reduced response to your greetings,but he follows your commands well. He exhibits excessive attentiveness to visual stimuli with a tendency to touch every object. The MRI of his brain showed bilateral damage to the amygdala and the neighboring temporal cortex. Which of the following medications is found to be beneficial to reduce sexual behavioral abnormalities in patients with this disease?