A 41-year-old male with episodic migraines is prescribed Lasmiditan for acute treatment. Two hours after taking the medication, he develops dizziness, fatigue, and a strong sense of drowsiness. His vital signs are stable, and he denies chest pain or shortness of breath. The physician advises him to avoid driving for several hours. Which of the following is the most likely cause of his symptoms?

A 50-year-old woman with migraines and a history of stable coronary artery disease is prescribed Lasmiditan 50 mg for acute treatment. She responds well to the medication during her first attack and asks about its efficacy compared to her previous treatments. In clinical trials, what was the primary efficacy endpoint used to evaluate Lasmiditan’s effectiveness for acute migraine treatment?

A 45-year-old man with a history of coronary artery disease and migraines is seeking acute migraine treatment. He cannot use triptans due to his cardiovascular history. Which of the following is a key advantage of lasmiditan over triptans in this patient?

A 34-year-old woman with a history of migraine with aura presents to the clinic seeking treatment options. She has a history of hypertension and stable coronary artery disease and reports that her previous triptan therapy (sumatriptan) caused chest tightness. The physician recommends a new medication, Lasmiditan, which is effective for migraines but lacks vasoconstrictive properties. Which of the following best describes the mechanism of action of Lasmiditan?

A 6-month-old infant with isovaleric acidemia is stable on a leucine-restricted diet and carnitine supplementation. The parents ask about long-term complications and monitoring. Which of the following is the most important long-term monitoring parameter for this patient?

A 2-week-old infant with known isovaleric acidemia is brought to the emergency department with vomiting, lethargy, and tachypnea. Blood gas analysis reveals severe metabolic acidosis. What is the most appropriate immediate management for this patient?

A 9-month-old boy with a history of recurrent vomiting, developmental delay, and metabolic acidosis is diagnosed with isovaleric acidemia. The pediatric metabolic specialist discusses a long-term treatment plan with the parents. Which of the following is the most effective long-term management strategy for this child?

A 2-week-old infant presents with vomiting, poor feeding, lethargy, and irritability. The parents mention that the baby’s urine has a ‘sweaty feet’ odor. Laboratory tests reveal high anion gap metabolic acidosis and hyperammonemia. A metabolic workup confirms the diagnosis of an organic acidemia. Which enzyme is deficient in this disorder?

A 3-day-old newborn is brought to the emergency department due to poor feeding, lethargy, and vomiting. The baby was born at term via an uneventful vaginal delivery. On examination, the infant is hypotonic, with tachypnea and a “sweaty feet” odor. Laboratory studies reveal severe metabolic acidosis, anion gap elevation, and hyperammonemia. Newborn screening results show elevated C5-acylcarnitine levels. Which of the following tests would most likely confirm the diagnosis?

A 3-day-old newborn presents with poor feeding, vomiting, lethargy, and a “sweaty feet” odor. Laboratory tests reveal metabolic acidosis, hyperammonemia, and elevated urinary organic acids. What is the most likely diagnosis?